AAMDC (adipogenesis associated Mth938 domain containing) is a multifunctional protein with roles in both metabolic regulation and cancer progression. In normal physiology, AAMDC promotes preadipocyte differentiation and adipogenesis 1, with its expression regulated through alternative polyadenylation and microRNA control 1. The short AAMDC isoform demonstrates higher translation efficiency and promotes bovine preadipocyte differentiation 1. In cancer contexts, AAMDC functions as an oncogene amplified in estrogen receptor-positive breast cancers, where it regulates metabolic enzymes in folate, methionine, and lipid metabolism pathways 2. AAMDC controls PI3K-AKT-mTOR signaling by regulating ATF4 and MYC translation, enabling estrogen-independent tumor growth 2. AAMDC interacts with RabGAP1L and localizes to endolysosomes 2. In gastric cancer, AAMDC mediates autophagy through the AAMDC/MYC/ATF4/Sesn2 pathway to promote tumorigenesis 3. Beyond cancer, AAMDC variants are associated with hepatitis B susceptibility in genome-wide association studies 4, and differential AAMDC expression occurs in Toxoplasma gondii-infected macrophages, potentially affecting immune responses 5. AAMDC-overexpressing tumors exhibit sensitivity to PI3K-mTOR inhibitors combined with anti-estrogens, suggesting therapeutic potential 2.