Most Researched

Genes ranked by total PubMed publication count — the most-studied genes in biology.

Filter by chromosome
1–50 of 20,598 genesranked by Most Researched
#GeneNameChrTagsPubMed Papers
1TP53tumor protein p5317Hub GeneTranscription Factor
12K
2EGFRepidermal growth factor receptor7Hub GeneKinase
6,679
3TNFtumor necrosis factor6Hub GeneOMIM Disease Gene
6,446
4IL6interleukin 67Hub GeneFDA Approved Target
5,468
5APOEapolipoprotein E19Hub GeneTransporter
5,224
6VEGFAvascular endothelial growth factor A6FDA Approved TargetOMIM Disease Gene
5,212
7TGFB1transforming growth factor beta 119Hub GeneFDA Approved Target
5,005
8HIF1Ahypoxia inducible factor 1 subunit alpha14Hub GeneTranscription Factor
3,910
9MTHFRmethylenetetrahydrofolate reductase1OMIM Disease GeneHighly Studied
3,862
10AKT1AKT serine/threonine kinase 114Hub GeneKinase
3,746
11STAT3signal transducer and activator of transcription 317Highly ConstrainedHub Gene
3,704
12ESR1estrogen receptor 16Hub GeneReceptor
3,639
13IL10interleukin 101Hub GeneHighly Studied
3,486
14BRCA1BRCA1 DNA repair associated17DNA RepairHomologous Recombination
3,447
15NFKB1nuclear factor kappa B subunit 14Highly ConstrainedHub Gene
3,393
16CTNNB1catenin beta 13Highly ConstrainedHub Gene
3,365
17ERBB2erb-b2 receptor tyrosine kinase 217Hub GeneKinase
3,351
18IL1Binterleukin 1 beta2Hub GeneFDA Approved Target
3,215
19APPamyloid beta precursor protein21Hub GeneFDA Approved Target
3,196
20MMP9matrix metallopeptidase 920Hub GeneProtease
3,163
21KRASKRAS proto-oncogene, GTPase12Highly ConstrainedHub Gene
3,054
22HLA-DRB1major histocompatibility complex, class II, DR beta 16Hub GeneOMIM Disease Gene
2,871
23PTENphosphatase and tensin homolog10Hub GeneTumor Suppressor
2,819
24TLR4toll like receptor 49Hub GeneReceptor
2,775
25ACEangiotensin I converting enzyme17Hub GeneProtease
2,770
26BRAFB-Raf proto-oncogene, serine/threonine kinase7Highly ConstrainedHub Gene
2,750
27ARandrogen receptorXHighly ConstrainedHub Gene
2,709
28MYCMYC proto-oncogene, bHLH transcription factor8Highly ConstrainedHub Gene
2,701
29CDKN2Acyclin dependent kinase inhibitor 2A9Hub GeneTumor Suppressor
2,698
30CD274CD274 molecule9Hub GeneReceptor
2,646
31ABCB1ATP binding cassette subfamily B member 17TransporterClinical Trials
2,568
32MTORmechanistic target of rapamycin kinase1Highly ConstrainedHub Gene
2,567
33BDNFbrain derived neurotrophic factor11Highly ConstrainedHub Gene
2,558
34CXCL8C-X-C motif chemokine ligand 84Hub GeneClinical Trials
2,501
35VDRvitamin D receptor12ReceptorTranscription Factor
2,491
36ADIPOQadiponectin, C1Q and collagen domain containing3Hub GeneOMIM Disease Gene
2,463
37CRPC-reactive protein1Hub GeneHighly Studied
2,459
38SLC6A4solute carrier family 6 member 417TransporterFDA Approved Target
2,401
39MAPK1mitogen-activated protein kinase 122Hub GeneKinase
2,336
40PTGS2prostaglandin-endoperoxide synthase 21Highly ConstrainedHub Gene
2,315
41PPARGperoxisome proliferator activated receptor gamma3Hub GeneReceptor
2,275
42GSTM1glutathione S-transferase mu 11Hub GeneHighly Studied
2,269
43SNCAsynuclein alpha4Hub GeneClinical Trials
2,255
44CDH1cadherin 116Hub GeneOMIM Disease Gene
2,233
45BCL2BCL2 apoptosis regulator18ApoptosisHub Gene
2,225
46HLA-Bmajor histocompatibility complex, class I, B6Hub GeneOMIM Disease Gene
2,221
47MAPTmicrotubule associated protein tau17Hub GeneOMIM Disease Gene
2,219
48MDM2MDM2 proto-oncogene12ApoptosisHighly Constrained
2,215
49BRCA2BRCA2 DNA repair associated13DNA RepairHomologous Recombination
2,208
50NOS3nitric oxide synthase 37Hub GeneClinical Trials
2,192