1–50 of 20,598 genesranked by Most Researched

#	Gene	Name	Chr	Tags	PubMed Papers
1	TP53	tumor protein p53	17	Transcription FactorTumor Suppressor	12K
2	EGFR	epidermal growth factor receptor	7	KinaseOncogene	6,679
3	TNF	tumor necrosis factor	6	OMIM Disease GeneHighly Studied	6,446
4	IL6	interleukin 6	7	FDA Approved TargetOMIM Disease Gene	5,468
5	APOE	apolipoprotein E	19	TransporterOMIM Disease Gene	5,224
6	VEGFA	vascular endothelial growth factor A	6	FDA Approved TargetOMIM Disease Gene	5,212
7	TGFB1	transforming growth factor beta 1	19	FDA Approved TargetOMIM Disease Gene	5,005
8	HIF1A	hypoxia inducible factor 1 subunit alpha	14	Transcription FactorHighly Studied	3,910
9	MTHFR	methylenetetrahydrofolate reductase	1	OMIM Disease GeneHighly Studied	3,862
10	AKT1	AKT serine/threonine kinase 1	14	KinaseOncogene	3,746
11	STAT3	signal transducer and activator of transcription 3	17	Highly ConstrainedTranscription Factor	3,704
12	ESR1	estrogen receptor 1	6	ReceptorFDA Approved Target	3,639
13	IL10	interleukin 10	1	Clinical TrialsHighly Studied	3,486
14	BRCA1	BRCA1 DNA repair associated	17	DNA RepairHomologous Recombination	3,447
15	NFKB1	nuclear factor kappa B subunit 1	4	Highly ConstrainedTranscription Factor	3,393
16	CTNNB1	catenin beta 1	3	Highly ConstrainedClinical Trials	3,365
17	ERBB2	erb-b2 receptor tyrosine kinase 2	17	KinaseReceptor	3,351
18	IL1B	interleukin 1 beta	2	FDA Approved TargetHighly Studied	3,215
19	APP	amyloid beta precursor protein	21	FDA Approved TargetOMIM Disease Gene	3,196
20	MMP9	matrix metallopeptidase 9	20	ProteaseClinical Trials	3,163
21	KRAS	KRAS proto-oncogene, GTPase	12	Highly ConstrainedOncogene	3,054
22	HLA-DRB1	major histocompatibility complex, class II, DR beta 1	6	OMIM Disease GeneHighly Studied	2,871
23	PTEN	phosphatase and tensin homolog	10	Tumor SuppressorOMIM Disease Gene	2,819
24	TLR4	toll like receptor 4	9	ReceptorClinical Trials	2,775
25	ACE	angiotensin I converting enzyme	17	ProteaseFDA Approved Target	2,770
26	BRAF	B-Raf proto-oncogene, serine/threonine kinase	7	Highly ConstrainedKinase	2,750
27	AR	androgen receptor	X	Highly ConstrainedReceptor	2,709
28	MYC	MYC proto-oncogene, bHLH transcription factor	8	Highly ConstrainedOncogene	2,701
29	CDKN2A	cyclin dependent kinase inhibitor 2A	9	Tumor SuppressorOMIM Disease Gene	2,698
30	CD274	CD274 molecule	9	ReceptorFDA Approved Target	2,646
31	ABCB1	ATP binding cassette subfamily B member 1	7	TransporterClinical Trials	2,568
32	MTOR	mechanistic target of rapamycin kinase	1	Highly ConstrainedKinase	2,567
33	BDNF	brain derived neurotrophic factor	11	Highly ConstrainedHighly Studied	2,558
34	CXCL8	C-X-C motif chemokine ligand 8	4	Clinical TrialsHighly Studied	2,501
35	VDR	vitamin D receptor	12	ReceptorTranscription Factor	2,491
36	ADIPOQ	adiponectin, C1Q and collagen domain containing	3	OMIM Disease GeneHighly Studied	2,463
37	CRP	C-reactive protein	1	Highly StudiedExperimental GO Evidence	2,459
38	SLC6A4	solute carrier family 6 member 4	17	TransporterFDA Approved Target	2,401
39	MAPK1	mitogen-activated protein kinase 1	22	KinaseClinical Trials	2,336
40	PTGS2	prostaglandin-endoperoxide synthase 2	1	Highly ConstrainedFDA Approved Target	2,315
41	PPARG	peroxisome proliferator activated receptor gamma	3	ReceptorTranscription Factor	2,275
42	GSTM1	glutathione S-transferase mu 1	1	Highly StudiedExperimental GO Evidence	2,269
43	SNCA	synuclein alpha	4	Clinical TrialsOMIM Disease Gene	2,255
44	CDH1	cadherin 1	16	OMIM Disease GeneHighly Studied	2,233
45	BCL2	BCL2 apoptosis regulator	18	ApoptosisOncogene	2,225
46	HLA-B	major histocompatibility complex, class I, B	6	OMIM Disease GeneHighly Studied	2,221
47	MAPT	microtubule associated protein tau	17	OMIM Disease GeneHighly Studied	2,219
48	MDM2	MDM2 proto-oncogene	12	ApoptosisHighly Constrained	2,215
49	BRCA2	BRCA2 DNA repair associated	13	DNA RepairHomologous Recombination	2,208
50	NOS3	nitric oxide synthase 3	7	Clinical TrialsHighly Studied	2,192