ABCA8 (ATP binding cassette subfamily A member 8) is a transmembrane transporter that primarily functions in cholesterol efflux and lipid metabolism. The protein catalyzes ATP-dependent efflux of cholesterol and taurocholate 1. ABCA8 interacts with ABCA1 to potentiate cholesterol efflux to lipid-free APOA1, which regulates high-density lipoprotein cholesterol (HDL-C) levels 1. Mechanistically, ABCA8 facilitates cholesterol efflux through direct interaction with ABCA1, enhancing the efficiency of cholesterol removal from cells 1. In the nervous system, ABCA8 plays a crucial role in myelination by interacting with chondroitin sulfate proteoglycan 4 (CSPG4) and modulating oligodendrocyte precursor cell numbers and cerebellar myelination 2. Disease relevance includes associations with hypoalphalipoproteinemia, where damaging ABCA8 variants are found in individuals with low HDL-C levels 3. Additionally, ABCA8 functions as a tumor suppressor in various cancers including hepatocellular carcinoma, gastric cancer, lung adenocarcinoma, and breast cancer, where its downregulation promotes tumor progression and metastasis 4567. Clinically, ABCA8 expression levels serve as prognostic biomarkers in multiple cancer types and may represent therapeutic targets for cholesterol metabolism disorders and cancer treatment.