ABCF2 is a cytosolic ATP-binding cassette transporter that functions as a negative regulator of cellular osmotic stress responses and ion channel activity. In epithelial cells, ABCF2 interacts with the actin-binding protein α-actinin-4 in response to hypotonic stress, and this interaction suppresses volume-sensitive outwardly rectifying anion channels (VSOR), thereby inhibiting regulatory volume decrease (RVD) 1. ABCF2 is an NRF2 target gene containing a functional antioxidant response element in its promoter 2. The gene contributes to cisplatin resistance in ovarian cancer cells through NRF2-dependent transcriptional regulation; ABCF2 overexpression decreases apoptosis and increases cell viability following cisplatin treatment, while knockdown sensitizes resistant cells to chemotherapy 2. ABCF2 has been identified as a hub gene associated with bladder urothelial carcinoma and metabolic syndrome, correlating with clinicopathological characteristics and patient prognosis 3. Genome-wide association studies identified ABCF2 as a locus influencing both IgA and IgG glycosylation, suggesting involvement in immune regulation 4. Additionally, ABCF2 may function as a disaggregase during animal development 5. A heterozygous pathogenic variant (c.1253T>G p.Phe418Cys) in ABCF2's ATP hydrolysis domain has been associated with interstitial cystitis and suspected neuropathy, implicating altered ATP metabolism in nociceptive responses 6.