ABHD14A is a serine hydrolase family member with emerging roles in neurological development and disease susceptibility. While its precise enzymatic function remains cryptic 1, ABHD14A shows high sequence similarity to ABHD14B, a lysine deacetylase, suggesting potential deacetylase activity, though this requires functional validation 1. The gene exhibits cytoplasmic localization and is implicated in granule neuron development pathways 2. ABHD14A has been identified as a novel susceptibility gene for developmental language disorder (DLD), with compound heterozygous variants including splice-site and missense variants (Leu230Arg) that significantly affect protein stability and structure 3. Additionally, ABHD14A was identified as an autism spectrum disorder candidate gene through homozygous haplotype mapping 4. In breast cancer, ABHD14A is downregulated in tumors with visceral organ metastasis, suggesting potential involvement in metastatic processes 5. Recently, plasma ABHD14A protein was associated with incident dementia risk in the context of the MIND diet (HR: 1.23), implicating it in neural signaling and neuroprotective pathways 6. ABHD14A expression is upregulated in certain tissues when other serine hydrolases are absent 7, indicating possible redundant enzymatic roles.