ABI3BP (ABI family member 3 binding protein) is an extracellular matrix structural protein that plays diverse roles in disease pathogenesis and cellular homeostasis 1. The protein functions as a regulator of extracellular matrix organization and cellular senescence processes 2. In osteoarthritis, ABI3BP is upregulated in damaged cartilage and promotes chondrocyte senescence and ECM degradation, with its knockdown reducing senescence-associated markers and protecting against disease progression 2. The protein demonstrates antiviral properties by maintaining actin cytoskeleton integrity and supporting type I interferon signaling pathways, as ABI3BP depletion increases viral replication and reduces interferon pathway activation 3. In cancer contexts, ABI3BP typically functions as a tumor suppressor, being downregulated in multiple cancer types including esophageal carcinoma, where it inhibits proliferation, migration, and invasion 41. However, ABI3BP shows complex disease associations, being upregulated in Kashin-Beck disease patients and serving as a susceptibility gene 5. In renal aging, elevated ABI3BP promotes ferroptosis and cellular aging by inhibiting Klotho expression 6. The protein also shows differential expression in severe preeclampsia, particularly in early-onset forms 7, suggesting roles in placental development and pregnancy complications.