ACBD7 (acyl-CoA binding domain containing 7) is a gene located on chromosome 10 that encodes a protein functioning as a metabolic regulator with dual roles in lipid binding and neuroendocrine signaling. Structurally, ACBD7 binds medium- and long-chain acyl-CoA esters and participates in fatty acid metabolic processes [UniProt]. Functionally, ACBD7 produces a splice variant isoform expressed in hypothalamic POMC and GABAergic neurons of the arcuate nucleus, which is processed into the bioactive peptide nonadecaneuropeptide (NDN) 1. NDN acts as a potent anorexigenic signal through an endozepine G protein-coupled receptor and the melanocortin system, integrating leptin signaling to control food intake and energy expenditure 1. ACBD7 expression varies during development; mRNA levels in abdominal adipose tissue are age-regulated in broiler chickens 2. Clinically, ACBD7 variants are associated with obesity susceptibility 1 and have been identified in anorexia nervosa patients 3, suggesting involvement in appetite regulation disorders. Additionally, ACBD7 expression appears altered in bladder cancer, with urinary exosomal ACBD7 mRNA showing diagnostic potential when combined with other markers 4. The gene represents an evolutionarily dynamic region showing recurrent structural variation across primates 5.