ACKR1 is an atypical chemokine receptor expressed on endothelial cells that functions as a scavenger receptor for chemokines including CXCL8 and CXCL12 1. Beyond immune regulation, ACKR1+ endothelial cells play critical roles in pathological tissue remodeling. In liver cirrhosis, ACKR1+ endothelial cells expand within fibrotic niches and enhance leucocyte transmigration, contributing to pro-fibrogenic microenvironments 2. In aortic dissection, elevated ACKR1 expression on endothelial cells drives macrophage migration and pro-inflammatory polarization through the NF-κB/SPP1 signaling pathway, promoting disease progression; ACKR1 knockdown suppresses this pathway and attenuates disease severity 3. ACKR1+ endothelial cells are universal tumor endothelial markers implicated in immunomodulation beyond angiogenesis 4. In heart failure, ACKR1+ endothelial cells associate with fibrosis and myocardial degeneration 5, though ACKR1+ endothelial injection preserves cardiac function after injury 6. In lung fibrosis, ACKR1+ venous endothelial cells exhibit persistent activated states in aging that fail to resolve, impairing recovery 7. In rectal cancer, ACKR1+ endothelial cells correlate with CD8+ T cell infiltration after neoadjuvant therapy and support antigen presentation 8. These findings establish ACKR1+ endothelial cells as key mediators of inflammatory and fibrotic pathology across multiple organ systems.