ACOXL (acyl-CoA oxidase like) is a gene located on chromosome 2 that encodes a protein involved in fatty acid beta-oxidation pathways. Based on GO annotations, ACOXL exhibits acyl-CoA oxidase activity and localizes to the cytosol and peroxisomal matrix, where it participates in fatty acid beta-oxidation using acyl-CoA oxidase [GO annotations]. The protein contains flavin adenine dinucleotide binding and fatty acid binding domains, consistent with its role in lipid metabolism. ACOXL has emerged as a potential diagnostic biomarker across multiple diseases. In cardiovascular disease, ACOXL was identified as a diagnostic marker for atherosclerosis using machine learning approaches and showed good predictive performance across multiple datasets 1. The gene also showed differential expression in obesity-related asthma, where RNA sequencing data from obese versus control mice demonstrated altered ACOXL expression in lung tissues 2. In cancer research, ACOXL has been investigated as a potential biomarker, with elevated expression identified in prostate tissue compared to other organs 3. Additionally, ACOXL-AS1, the antisense RNA to ACOXL, appears to function as a tumor suppressor in endometrial endometrioid carcinoma, where overexpression inhibited cell proliferation, migration, and invasion 4. The protein has also been detected in serum proteomics studies of pulmonary cystic echinococcosis patients, suggesting potential clinical utility in monitoring treatment responses 5.