ACTL6A (actin-like 6A) is a critical chr3 remodeling factor that functions as a core component of multiple ATP-dependent chr3 remodeling complexes, including SWI/SNF, TIP60/NuA4 histone acetyltransferase, and INO80 complexes 1. The protein plays essential roles in transcriptional regulation by altering DNA-nucleosome topology and promoting histone acetylation 1. ACTL6A is particularly important in neural development, where it functions in the npBAF complex required for neural progenitor proliferation and self-renewal 2. Mechanistically, ACTL6A acts through multiple pathways including the HIF-1α/ACTL6A/H3K9ac axis, which is critical for maintaining pluripotency in induced pluripotent stem cells 2. The protein also interacts with oncogenic factors like MYC and VPS72 to promote cancer progression 3. In disease contexts, ACTL6A exhibits oncogenic properties across multiple cancer types, promoting cell survival by protecting against ferroptosis through glutathione synthesis regulation 4 and contributing to chemotherapy resistance 5. Clinically, ACTL6A overexpression correlates with poor overall survival, larger tumor size, and higher tumor grade, establishing it as both a prognostic biomarker and potential therapeutic target 6.