ACTR3C (actin-related protein 3C) is a gene located on chromosome 7 that may function in cellular processes related to tissue remodeling and mechanical response. The gene has been identified as one of the top hypermethylated genes in keloid tissue compared to normal skin 1, suggesting altered epigenetic regulation in this fibroproliferative disorder. ACTR3C ranked among the top 10 statistically significant differentially methylated genes in keloid pathogenesis 2, indicating potential involvement in the aberrant wound healing response characteristic of keloids. More recently, ACTR3C was found to be significantly regulated within tight junction signaling pathways in human growth plate cartilage subjected to biomechanical loading 3, suggesting a role in mechanotransduction and cellular response to mechanical stress. The Gene Ontology annotation indicating localization to extracellular exosomes implies potential involvement in intercellular communication. While UniProt suggests a role in suppressing metastatic potential in lung adenocarcinoma, this function is not supported by the provided abstracts. Further investigation is needed to establish ACTR3C's specific molecular mechanisms and its clinical relevance beyond its association with altered methylation patterns in keloid tissue.