ADAMTS10 is a secreted metalloprotease that plays critical roles in extracellular matrix (ECM) assembly and organization, particularly in microfibril formation 1. The protein undergoes proteolytic activation by subtilisin-like proprotein convertases and is widely expressed in mesenchymal tissues during development, with particularly strong expression in developing lung, bone, and craniofacial regions 1. ADAMTS10 functions in ECM protein secretion and assembly, working cooperatively with ADAMTS17 to regulate fibronectin deposition and fibrillin-1 organization 23. Mechanistically, ADAMTS10 appears to modulate ECM formation at later stages compared to ADAMTS17, possibly regulating spatio-temporal deposition of fibrillin isoforms 3. Loss-of-function mutations in ADAMTS10 cause Weill-Marchesani syndrome, characterized by short stature, joint contractures, and connective tissue abnormalities, indicating its essential role in skeletal development and growth plate function 45. The protein also demonstrates tumor suppressor activity in gastric cancer, where it inhibits cell aggressiveness through the JAK/STAT/c-MYC pathway and reprograms macrophages to create an anti-malignant microenvironment 6. ADAMTS10's broad expression pattern and multiple disease associations underscore its fundamental importance in connective tissue homeostasis and development 7.