ADGRB1 is an adhesion G protein-coupled receptor characterized by a bipartite structure combining a large extracellular domain with a seven-transmembrane signaling domain 1. It functions primarily as an inhibitor of angiogenesis and plays critical roles in immune regulation and neuronal development. In immunological contexts, ADGRB1 mediates phagocytosis and leukocyte activation 23. The receptor regulates dendritic spine and excitatory synapse development, interacting with autism-relevant proteins 4. In cancer biology, ADGRB1 suppresses intrahepatic cholangiocarcinoma progression by preventing MDM2-mediated p53 polyubiquitination, thereby activating p53 signaling 5. ADGRB1 has emerged as a neurodevelopmental disorder-associated gene, identified through integrated analysis of de novo variants 6. In Parkinson's disease models, reduced ADGRB1 expression correlates with dopaminergic neuronal loss in the substantia nigra, and ADGRB1 overexpression provides neuroprotection against MPP+-induced toxicity 7. Loss of full-length ADGRB1 in mice produces social deficits, increased seizure susceptibility, altered brain development, and reduced neuron density with increased apoptosis in the hippocampus 4. These findings position ADGRB1 as a potential therapeutic target for neurodegenerative and neurodevelopmental disorders, as well as certain cancers.