ADGRF3 (adhesion G protein-coupled receptor F3), also known as GPR113, is an orphan adhesion GPCR belonging to the family 2B subfamily of G protein-coupled receptors 1. The receptor contains a long N-terminal extracellular domain of approximately 696 amino acids with a peptide hormone-binding domain and a G protein-coupled receptor proteolytic site, characteristic of adhesion GPCRs 2. ADGRF3 functions as a G protein-coupled receptor with adenylate cyclase-activating signaling capacity and is localized to the plasma membrane 1. Expression analysis demonstrates that ADGRF3 is highly restricted to a subset of taste receptor cells, suggesting a specialized sensory function 2. Recent studies have identified ADGRF3 as significantly upregulated in uterine corpus endometrial carcinoma tissues, with potential roles in cancer-related immune infiltration and clinical outcomes 3. However, CRISPR/Cas9 knockout studies in mice revealed that individual disruption of Adgrf3 does not impair male fertility, indicating the gene is not essential for reproductive function, at least in the absence of genetic redundancy 4. The specific physiological roles of ADGRF3 remain largely undefined, warranting further investigation into its ligand interactions and signaling mechanisms.