AKAP11 (A-kinase anchoring protein 11) serves as a critical scaffold protein that anchors protein kinase A (PKA) regulatory subunits and couples PKA signaling to autophagy regulation in neurons 1. The protein functions as an autophagy receptor that mediates selective degradation of the PKA-RI complex through interactions with autophagy-related proteins VAPA/B and SPHKAP 12. AKAP11 contains an LC3-interacting region (LIR) that enables PKA regulation by upstream signals and autophagy-dependent degradation, with autophagosomes serving as platforms for PKA signaling modulation 2. Loss of AKAP11 disrupts compartment-specific PKA and GSK3α/β activities, impairing synaptic transmission and neurotransmission 1. AKAP11 is clinically significant as protein-truncating variants confer substantial risk for both bipolar disorder and schizophrenia through loss-of-function mechanisms 34. The gene emerged as a definitive shared risk factor with an odds ratio of 7.06 for bipolar disorder 3. Mouse models with AKAP11 deficiency exhibit EEG abnormalities characteristic of schizophrenia patients, including increased gamma power and attenuated auditory responses 5. The protein's interaction with GSK3β, lithium's hypothesized target, provides mechanistic insight into mood stabilizer action 34.