AKAP6 (A-kinase anchoring protein 6) is a scaffolding protein that localizes protein kinase A (PKA) regulatory subunits to the nuclear envelope and sarcoplasmic reticulum, enabling localized cAMP-PKA signaling. 1 AKAP6 physically interacts with phospholamban at the sarcoplasmic reticulum and promotes calcium uptake by SERCA, facilitating muscle relaxation. 1 Additionally, AKAP6 functions as a key organizer of nuclear envelope microtubule-organizing centers (MTOCs) by anchoring centrosomal proteins through spectrin repeats and linking the Golgi to the nucleus via AKAP9. 2 In skeletal muscle, AKAP6 is essential for myoblast differentiation and muscle regeneration through a positive feedback loop with myogenin, a transcription factor that induces AKAP6 expression while AKAP6 promotes myogenin expression. 34 AKAP6 also regulates NE-MTOC formation, which is required for cardiomyocyte hypertrophy and osteoclast bone resorption activity. 2 Clinically, AKAP6 variants associate with cognitive performance in older adults 5 and have been identified as candidate disease genes in intellectual disability. 6 A common variant (rs17522122) colocalizes across periodontal disease, type 2 diabetes, and bone mineral density. 7 Recent epigenome-wide studies identified differential DNA methylation near AKAP6 associated with Lewy body pathology in Parkinson's disease and dementia with Lewy bodies. 8