AKAP9 (A-kinase anchoring protein 9) is a scaffolding protein that coordinates the cellular localization and function of protein kinase A (PKA), playing critical roles in cardiac electrophysiology and cellular organization 1. The protein regulates the phosphorylation of slowly activating delayed rectifier potassium channels (IKs) and enhances Golgi localization and stability of PKA RIIα subunits 21. AKAP9 functions in centrosome duplication, cell cycle progression, and maintenance of cellular membrane integrity 3. In cardiac tissue, AKAP9 modulates membrane repolarization through potassium channel regulation, with loss-of-function variants predisposing to life-threatening ventricular arrhythmias 4. Disease associations with AKAP9 mutations remain disputed, with multiple studies showing limited evidence for causation of Long QT syndrome 11 5. However, case reports describe patients with AKAP9 frameshift mutations presenting with sudden cardiac arrest, Brugada syndrome, and recurrent syncope requiring defibrillator implantation 42. Additionally, AKAP9 frameshift mutations occur frequently in gastric and colorectal cancers with high microsatellite instability, suggesting broader roles in oncogenesis 3. The protein's multifaceted functions in PKA signaling, cellular organization, and ion channel regulation underscore its importance in both cardiac physiology and cancer biology.