AKIRIN2 is a molecular adapter protein that serves critical roles in nuclear protein quality control, immune regulation, and cellular development. Its primary function involves mediating nuclear import of proteasomes by forming homodimers that directly bind fully assembled 20S proteasomes and bridge them to nuclear import receptor IPO9, facilitating pre-assembled proteasome complex import through nuclear pores 1. During mitosis, AKIRIN2 orchestrates the dynamic re-import of proteasomes into newly formed daughter nuclei, and its absence leads to accumulation of nuclear proteins like MYC 1. AKIRIN2 functions as a transcriptional cofactor without DNA-binding capability, regulating gene expression through interactions with chr6 remodelers, transcription factors, and histone H3.1 2. In immune responses, it promotes IL-6 production and adaptive immunity, with particular involvement in neutrophil and B-cell function 2. AKIRIN2 is essential for neuronal maintenance, as its loss in cortical neurons triggers p53-mediated necroptosis and progressive neurodegeneration 3. Clinically, AKIRIN2 overexpression correlates with poor prognosis in gastric adenocarcinoma and promotes angiogenesis in cholangiocarcinoma via IL-6/STAT3/VEGFA signaling 45. Additionally, genome-wide studies have identified AKIRIN2 expression changes in diabetic kidney disease 6.