AKT3 is a serine/threonine protein kinase that plays crucial roles in brain development, immune responses, and cancer progression. AKT3 is essential for normal brain development, with germline mutations causing megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome through dysregulated PI3K-AKT signaling 1. In immune responses, AKT3 functions as a key effector in antiviral signaling pathways, where it directly phosphorylates IRF3 at Ser385 to promote type I interferon production following viral infection 23. This occurs through PARP9-mediated recruitment of PI3K/AKT3 signaling or via 7-dehydrocholesterol-induced AKT3 activation. In cancer, AKT3 promotes tumor progression and metastasis through multiple mechanisms. It drives epithelial-mesenchymal transition by facilitating nuclear accumulation of Snail transcription factor 4, while in multiple myeloma, AKT3 expression is regulated through m6A-dependent mRNA stabilization 5. AKT3 is particularly elevated in melanomas, contributing to apoptosis resistance and drug resistance 6. Additionally, circular RNA derived from AKT3 (circAKT3) acts as a protein scaffold promoting cancer cell proliferation and metastasis 7. These diverse functions highlight AKT3's importance in development, immunity, and disease pathogenesis.