ALPG (alkaline phosphatase, germ cell) is a membrane-associated alkaline phosphatase with hydrolase activity capable of hydrolyzing various phosphate compounds. The gene encodes a metal ion-binding enzyme localized to the extracellular region and plasma membrane 1. ALPG is expressed during germ cell development, serving as a marker of early germ cell stages 2. In developmental contexts, ALPG activation occurs during the transition from primed to naive pluripotency in human stem cells, preceding activation of OCT4-distal enhancer and correlating with emergence of primitive endoderm and trophectoderm signatures 1. Genetically, ALPG variants show disease associations with steroid-sensitive nephrotic syndrome subphenotypes; SNPs in ALPG were significantly distributed between steroid-sensitive nephrotic syndrome without relapse and healthy controls 3. Additionally, ALPG has been identified as a prognostic mRNA in colorectal cancer pathways, participating in the lncRNA-miRNA-mRNA regulatory network involved in β-elemene's antitumor mechanisms 4. A placental eQTL study detected a suggestive association between ALPG variants (rs11678251) and reduced placental and newborn weight, though this finding was not replicated in larger meta-analyses 5. Overall, ALPG functions as both a developmental marker and a genetically variable gene with potential relevance to immunological and growth-related phenotypes.