AMFR — autocrine motility factor receptor

30 sources retrieved · Most recent: April 2026 · Index updated 3 months ago

187PubMed Papers

#2,285 · top 12% of 19K genes

21Diseases

top 10%

0Drugs

7Pathogenic Variants

top 58%

OMIM Disease GeneHub GeneReceptorTrendingExperimental GO EvidenceSwiss-Prot Reviewed

endoplasmic reticulumendoplasmic reticulum membranemembraneperinuclear region of cytoplasmspastic paraplegia 89, autosomal recessivebreast carcinomabreast cancerUterine leiomyoma

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autocrine motility factor receptor

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.

Disease Associations21

spastic paraplegia 89, autosomal recessiveOpen Targets

0.61Moderate

breast carcinomaOpen Targets

0.29Weak

breast cancerOpen Targets

0.23Weak

Uterine leiomyomaOpen Targets

0.22Weak

neurodegenerative diseaseOpen Targets

0.22Weak

neuropathyOpen Targets

0.20Weak

optic neuritisOpen Targets

0.18Weak

marfanoid habitus and intellectual disabilityOpen Targets

0.12Weak

Primary amenorrheaOpen Targets

0.12Weak

breast ductal adenocarcinomaOpen Targets

0.11Weak

neoplasmOpen Targets

0.10Suggestive

cancerOpen Targets

0.09Suggestive

obesityOpen Targets

0.08Suggestive

Alzheimer diseaseOpen Targets

0.08Suggestive

Ehlers-Danlos syndrome, musculocontractural typeOpen Targets

0.07Suggestive

papillary thyroid carcinomaOpen Targets

0.07Suggestive

thyroid cancerOpen Targets

0.07Suggestive

in situ carcinomaOpen Targets

0.07Suggestive

non-alcoholic steatohepatitisOpen Targets

0.07Suggestive

hepatocellular carcinomaOpen Targets

0.06Suggestive

Spastic paraplegia 89, autosomal recessiveUniProt

Pathogenic Variants7

NM_001144.6(AMFR):c.707+1G>ALikely pathogenic

Spastic paraplegia 89, autosomal recessive|Nonpapillary renal cell carcinoma|Thyroid cancer, nonmedullary, 1

★☆☆☆2024

NM_001144.6(AMFR):c.1092T>A (p.Cys364Ter)Pathogenic

not provided

★☆☆☆2023→ Residue 364

NM_001144.6(AMFR):c.254G>A (p.Trp85Ter)Pathogenic