ANKAR (ankyrin and armadillo repeat containing) is a protein-coding gene located on chromosome 2 that encodes a molecule containing ankyrin and armadillo repeat domains. Limited functional characterization is available in the provided literature. ANKAR was identified as a circulating extracellular vesicle (EV) protein associated with metastatic pancreatic ductal adenocarcinoma (PDAC) in a large-scale proteomics study of 124 individuals 1. Specifically, EVs with elevated ANKAR levels, alongside PSMB4 and RUVBL2, correlated with metastatic disease in PDAC patients 1. This suggests ANKAR may play a role in cancer progression or metastasis, though the molecular mechanisms remain unclear. ANKAR was also identified as one of 21 genes affected by a hemizygous 3.4 Mb deletion on chromosome 2.1-q32.3 in an aortic dissection patient, but haploinsufficiency of ANKAR was not demonstrated as causative for the observed phenotype 2. The protein's structural features—containing ankyrin and armadillo repeats—suggest potential roles in protein-protein interactions and cellular signaling, but direct functional studies are needed. Current evidence limits ANKAR to potential involvement in cancer metastasis, though clinical significance remains to be established.