ANKRD17 is a multifunctional ankyrin repeat-containing protein with roles spanning cell cycle regulation, innate immunity, and neurodevelopment. Mechanistically, ANKRD17 positively regulates viral pattern recognition through interaction with RIG-I, MDA5, and VISA, enhancing RLR-mediated activation of IRF-3 and NF-κB signaling 1. It also functions in antibacterial immunity by binding NOD1 and NOD2 receptors to promote inflammatory responses 2. In Drosophila, ANKRD17 ortholog functions in the Hippo pathway as a Yorkie co-factor, suggesting roles in cell proliferation control 3. Clinically, heterozygous loss-of-function ANKRD17 variants cause Chopra-Amiel-Gordon syndrome, characterized by intellectual disability, speech delay, developmental delay, growth failure, epilepsy, and predisposition to recurrent infections 3. Recent studies implicate ANKRD17 dysfunction in autism spectrum disorder through synaptic protein dysregulation and mitochondrial dysfunction 4. ANKRD17 also emerges as an ASD risk gene across diverse populations 5. Conversely, ANKRD17 overexpression in hepatocellular carcinoma activates pro-survival signaling and epithelial-mesenchymal transition, promoting metastatic progression 6. ANKRD17 shows reduced expression in sporadic colorectal tumors compared to normal tissue, suggesting potential tumor suppressor activity 7.