ANKRD45 is a novel ankyrin repeat protein that plays a conserved role in cell proliferation and cytokinesis. The protein contains two ankyrin repeat domains, which are protein-protein interaction motifs 1. During mitosis, ANKRD45 displays dynamic subcellular localization, with preferential concentration at the midbody ring during cytokinesis 1, consistent with its annotated localization to cleavage furrows and midbodies. Functionally, ANKRD45 is required for proper cell proliferation; its knockdown via siRNA or CRISPR/Cas9 induces apoptosis in cultured cells 1, and loss of ankrd45 in zebrafish results in hepatic cysts associated with increased cell apoptosis when combined with oncogenic KrasG12V expression 1. In disease contexts, ANKRD45 has emerged as a candidate risk gene in schizophrenia, showing disease-context-specific regulation where overexpression inhibits neuronal differentiation while knockdown promotes it 2. Additionally, ANKRD45 has been identified as a component of prognostic signatures in gastric adenocarcinoma 3 and shows aberrant DNA hypermethylation in hepatocellular carcinoma samples 4. These findings suggest ANKRD45 functions as a critical regulator of cell division with potential roles in cancer pathogenesis and psychiatric disease.