ANO3 (anoctamin 3) is a calcium-dependent phospholipid scramblase that primarily functions in regulating potassium channel activity, particularly by modulating KCNT1/Slack channel conductance 1. Unlike other anoctamins, ANO3 does not exhibit calcium-activated chloride channel activity. The protein localizes to the plasma membrane and cilium, where it facilitates phospholipid translocation and monoatomic ion transport. ANO3 mutations cause dystonia-24 (DYT24), a rare autosomal dominant isolated or combined dystonia typically presenting in adulthood 2. The disease mechanism involves calcium homeostasis dysfunction within broader network abnormalities affecting the basal ganglia, cerebellum, thalamus, and cortex 3. Clinical presentation varies with age of onset and variant location; younger patients with variants near the scrambling domain show more severe phenotypes including tremor, dystonic movements, and cognitive difficulties 2. Tremor is particularly prevalent in ANO3-dystonia, representing one of the highest prevalence rates among isolated dystonias 4. Clinically, ANO3-dystonia diagnosis remains challenging due to overlapping neurological symptoms 5. Recent findings suggest ANO3 variants may also contribute to neuronal excitability abnormalities in all-cause dementia pathogenesis 6, though functional studies are needed to clarify the relationship between phospholipid scrambling activity and disease phenotypes.