ANO7 (anoctamin 7) is a prostate-specific transmembrane protein that functions primarily as a calcium-dependent phospholipid scramblase rather than a chloride channel 1. The protein plays a crucial role in regulating cellular metabolism, particularly by modulating mitochondrial function and lipid metabolism pathways 2. ANO7 expression induces a metabolic shift toward glycolysis while downregulating oxidative phosphorylation, and it significantly alters cellular lipid composition 2. In prostate tissue, ANO7 demonstrates a heterogeneous expression pattern in luminal epithelial cells and is associated with androgen receptor signaling and arachidonic acid metabolism 3. The ANO7 mRNA shows unusual nuclear enrichment (89% in benign tissue, 78% in high-grade cancer), suggesting potential regulatory functions beyond protein coding 4. Clinically, ANO7 serves as both a biomarker and potential therapeutic target for prostate cancer. Germline variants, particularly rs77559646, are associated with aggressive prostate cancer and disrupt normal protein expression through splicing alterations 5. High ANO7 expression correlates with poor survival outcomes 6, while the protein interacts with various cellular components including vesicles and heat shock proteins 7, supporting its multifaceted role in prostate cancer pathogenesis.