ANXA8L1 (annexin A8 like 1) is a calcium-dependent phospholipid-binding protein localized to the cytoplasm, endosomes, and sarcolemma that mediates endosomal transport and vesicle membrane organization 1. The protein functions in cellular processes including inflammation, proliferation, differentiation, and apoptosis 1. Disease Relevance: ANXA8L1 expression is significantly upregulated in renal cell carcinoma (RCC) compared to normal kidney tissues, where higher expression correlates with worse overall survival and higher clinical grades 1. In non-small cell lung cancer (NSCLC), ANXA8L1 was identified as one of six key prognostic enhancer RNAs associated with metastasis, demonstrating predictive utility for metastatic disease 2. In cervical cancer (CESC), ANXA8L1 expression was negatively correlated with patient survival time 3. Clinical Significance: ANXA8L1 serves as a potential biomarker for cancer prognosis across multiple malignancies. The protein was also identified as an autoantigen in pemphigus vulgaris, a mucocutaneous blistering disease, suggesting immune-mediated involvement in autoimmune pathology 4. These findings position ANXA8L1 as a relevant therapeutic target and diagnostic marker in both neoplastic and autoimmune disease contexts.