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0 sources retrieved Β· Most recent: April 2026 Β· Index updated 14 days ago
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ARHGEF10L
Rho guanine nucleotide exchange factor 10 like
Chromosome 1 Β· 1p36.13
NCBI Gene: 55160Ensembl: ENSG00000074964.17HGNC: HGNC:25540UniProt: B4DTL3
23PubMed Papers
20Diseases
0Drugs
1Pathogenic Variants
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
SREBP signaling pathwayGTPase activator activitycytosolpositive regulation of stress fiber assemblyneurodegenerative diseaseAlzheimer diseaseplacental retentiongram-negative bacterial infections
✦AI Summary

AI summary not yet available. Showing NCBI Gene summary.

Rho guanine nucleotide exchange factor 10 like

⚠Limited data available β€” This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsβ“˜20
neurodegenerative diseaseOpen Targets
0.39Weak
Alzheimer diseaseOpen Targets
0.33Weak
placental retentionOpen Targets
0.28Weak
gram-negative bacterial infectionsOpen Targets
0.28Weak
benign chondrogenic neoplasmOpen Targets
0.27Weak
Rare genetic intellectual disability with developmental anomalyOpen Targets
0.27Weak
clear cell renal carcinomaOpen Targets
0.23Weak
ovarian neoplasmOpen Targets
0.22Weak
acute myeloid leukemiaOpen Targets
0.19Weak
neoplasmOpen Targets
0.19Weak
oral squamous cell carcinomaOpen Targets
0.19Weak
astrocytomaOpen Targets
0.19Weak
hepatocellular carcinomaOpen Targets
0.19Weak
melanomaOpen Targets
0.19Weak
esophageal adenocarcinomaOpen Targets
0.18Weak
gastric adenocarcinomaOpen Targets
0.18Weak
kidney neoplasmOpen Targets
0.18Weak
multiple myelomaOpen Targets
0.18Weak
ovarian serous adenocarcinomaOpen Targets
0.18Weak
T-cell acute lymphoblastic leukemiaOpen Targets
0.18Weak
Pathogenic Variants1
NM_018125.4(ARHGEF10L):c.3646G>A (p.Asp1216Asn)Likely pathogenic
Cerebral visual impairment and intellectual disability
β˜…β˜†β˜†β˜†2015β†’ Residue 1216
View on ClinVar β†—
Related Genes
RHOAProtein interaction71%ARHGEF17Shared pathway50%ARHGAP26Shared pathway40%ARHGEF10Shared pathway38%ARHGEF15Shared pathway29%ARHGEF11Shared pathway25%
Tissue Expression6 tissues
Liver
100%
Heart
29%
Lung
13%
Ovary
9%
Brain
6%
Bone Marrow
2%
Gene Interaction Network
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ARHGEF10LRHOAARHGEF17ARHGAP26ARHGEF10ARHGEF15ARHGEF11
PROTEIN STRUCTURE
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AlphaFoldAI-predicted Β· UniProt Q5VXI4
View on AlphaFold β†—
Constraintβ“˜
LOEUFβ“˜
0.65LoF Tolerant
pLIβ“˜
0.00Tolerant
Observed/Expected LoF0.54 [0.44–0.65]
RankingsWhere ARHGEF10L stands among ~20K protein-coding genes
  • #13,372of 20,598
    Most Researched23
  • #5,338of 5,498
    Most Pathogenic Variants1
  • #4,767of 17,882
    Most Constrained (LOEUF)0.65
Genes detectedARHGEF10L
Sources retrieved0 papers
Response timeβ€”