ARPC2 (actin related protein 2/3 complex subunit 2) is a critical component of the Arp2/3 complex that mediates actin polymerization and branched actin network formation in the cytoplasm 1. The protein functions as an actin-binding component that contacts the mother actin filament and provides force for cell motility through actin nucleation 1. ARPC2 plays essential roles in cellular processes including proliferation, migration, and invasion across multiple cancer types 234. In hepatocellular carcinoma, ARPC2 overexpression significantly promotes tumor cell proliferation and invasion, while its silencing inhibits these processes 2. Similarly, in breast cancer, ARPC2 upregulates epithelial-mesenchymal transition markers and activates TGF-β pathways to promote metastasis 3. ARPC2 is highly enriched in extracellular vesicles from metastatic cancer cells and enhances cancer cell growth and metastasis 5. The protein shows significant clinical relevance as its overexpression correlates with worse prognosis, higher tumor stage, and lymph node metastasis in multiple cancer types 234. ARPC2 has emerged as a potential therapeutic target, with inhibitors like benproperine demonstrating anti-metastatic effects by disrupting Arp2/3 complex function 1.