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GeneE
10 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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ARSH
arylsulfatase family member H
Chromosome X · Xp22.33
NCBI Gene: 347527Ensembl: ENSG00000205667.3HGNC: HGNC:32488UniProt: Q5FYA8
3PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
arylsulfatase activityendoplasmic reticulum lumenmembraneParkinson diseaseneoplasmMultiple sulfatase deficiencyLewy body dementia
✦AI Summary

Based on the provided abstracts, there is insufficient information to accurately describe the function of the ARSH (arylsulfatase family member H) gene located on the X chrX. While the gene name suggests it belongs to the arylsulfatase enzyme family and GO annotations indicate arylsulfatase activity in the endoplasmic reticulum lumen, none of the provided PubMed abstracts contain relevant information about this specific gene. The abstracts discuss unrelated topics including subacromial impingement syndrome diagnostic tests, bacterial arsenic resistance mechanisms (mentioning a different arsH gene in bacteria), and adolescent reproductive health programs (using ARSH as an acronym for Adolescent Reproductive and Sexual Health). The bacterial arsH gene mentioned encodes a methylarsenite oxidase involved in arsenic detoxification 12, but this appears to be a completely different gene from the human ARSH gene in question. Without appropriate research literature specifically addressing the human ARSH gene, its molecular function, biological processes, and clinical significance cannot be determined from the provided sources.

Sources cited
1
Describes a bacterial arsH gene encoding methylarsenite oxidase, unrelated to human ARSH
PMID: 27105594
2
Further describes bacterial arsH function in arsenic detoxification, distinct from human ARSH
PMID: 27730229
⚠Limited data available — This gene has 2 indexed publications. Summary and analysis may be incomplete.
Disease Associationsⓘ20
Parkinson diseaseOpen Targets
0.06Suggestive
neoplasmOpen Targets
0.05Suggestive
Multiple sulfatase deficiencyOpen Targets
0.05Suggestive
Lewy body dementiaOpen Targets
0.04Suggestive
non-small cell lung carcinomaOpen Targets
0.03Suggestive
gliomaOpen Targets
0.02Suggestive
chronic obstructive pulmonary diseaseOpen Targets
0.02Suggestive
breast cancerOpen Targets
0.02Suggestive
ovarian cancerOpen Targets
0.02Suggestive
liver cancerOpen Targets
0.02Suggestive
hepatocellular carcinomaOpen Targets
0.02Suggestive
cancerOpen Targets
0.02Suggestive
osteosarcomaOpen Targets
0.02Suggestive
hyperinsulinemic hypoglycemia, familial, 4Open Targets
0.01Suggestive
chronic hepatitis B virus infectionOpen Targets
0.01Suggestive
leiomyomaOpen Targets
0.01Suggestive
endometrial cancerOpen Targets
0.01Suggestive
recessive X-linked ichthyosisOpen Targets
0.01Suggestive
metachromatic leukodystrophyOpen Targets
0.01Suggestive
neuroblastomaOpen Targets
0.01Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
ARSKProtein interaction73%SUMF1Protein interaction73%ARSIProtein interaction73%
Tissue Expression6 tissues
Brain
100%
Heart
0%
Bone Marrow
0%
Ovary
0%
Liver
0%
Lung
0%
Gene Interaction Network
Click a node to explore
ARSHARSKSUMF1ARSI
PROTEIN STRUCTURE
Preparing viewer…
AlphaFoldAI-predicted · UniProt Q5FYA8
View on AlphaFold ↗
Constraintⓘ
LOEUFⓘ
1.50LoF Tolerant
pLIⓘ
0.00Tolerant
Observed/Expected LoF1.11 [0.84–1.50]
RankingsWhere ARSH stands among ~20K protein-coding genes
  • #18,805of 20,598
    Most Researched3
  • #15,155of 17,882
    Most Constrained (LOEUF)1.50
Genes detectedARSH
Sources retrieved10 papers
Response time—
📄 Sources
10▼
1
Clinical tests accuracy in diagnosing subacromial impingement syndrome: A systematic review.
PMID: 37051997
J Pak Med Assoc · 2023
1.00
2
New mechanisms of bacterial arsenic resistance.
PMID: 27105594
Biomed J · 2016
0.90
3
Adolescent health programming in India: a rapid review.
PMID: 32493471
Reprod Health · 2020
0.80
4
The organoarsenical biocycle and the primordial antibiotic methylarsenite.
PMID: 27730229
Metallomics · 2016
0.70
5
ARSH 1: Reproductive and sexual health problems of adolescents and young adults: a cross sectional community survey on knowledge, attitude and practice.
PMID: 23934098
Indian J Pediatr · 2013
0.60