ARVCF (Armadillo Repeat gene deleted in Velo-Cardio-Facial syndrome) is a p120 catenin family member with dual functions in cell adhesion and RNA processing. Primary function: ARVCF localizes to adherens junctions through cadherin binding and interacts with PDZ-domain proteins zonula occludens-1 and ZO-2, which regulate its subcellular localization between the plasma membrane and nucleus 1. Mechanism: ARVCF contributes to alternative splicing regulation through interaction with splicing factor hnRNPH2, functioning as a p53 target gene that modulates splicing patterns to support tumor suppression 2. The protein exhibits prominent cytoplasmic localization in cultured cells and is specifically detected in renal proximal tubules 3. Disease relevance: ARVCF hemizygosity contributes to velo-cardio-facial syndrome phenotypes 4. Genome-wide association studies demonstrate causal relationships between ARVCF expression in frontal cortex and nucleus accumbens with alcohol dependence; Arvcf knockout mice lack conditioned place preference for alcohol 5. ARVCF functions as a prognostic biomarker in breast cancer metastasis, identified through exosome-related gene analysis 6. Clinical significance: ARVCF serves as a therapeutic target in renal pelvis carcinoma 7 and is an autoantigen in endemic pemphigus foliaceus 8.