ATP6V1C2 encodes a subunit of the V1 complex of vacuolar H+-ATPase (V-ATPase), a multisubunit enzyme responsible for acidifying intracellular compartments and maintaining cellular pH homeostasis. The protein is essential for proper V-ATPase assembly and catalytic activity 1. ATP6V1C2 shows tissue-specific expression, being localized in ciliated cells and club cells of bronchial epithelium in yaks, where it may contribute to high-altitude adaptation 2. In renal physiology, ATP6V1C2 plays a critical role in distal tubular acidification, as loss-of-function mutations cause recessive distal renal tubular acidosis, a rare disorder characterized by hyperchloremic metabolic acidosis and impaired urinary acidification 13. The gene has emerged as a prognostic biomarker in colorectal cancer, where overexpression correlates with poor prognosis, reduced immune infiltration (particularly CD8+ T cells), and clinicopathological progression 4. ATP6V1C2 is also implicated in cancer biology through succinylation-related molecular activities and has been identified as part of prognostic signatures in colorectal cancer 5. Additionally, the gene shows potential as a therapeutic target, with molecular docking studies suggesting sensitivity to specific natural compounds 4.