AURKA (Aurora kinase A) is a mitotic serine/threonine kinase that serves as a critical regulator of cell cycle progression and chr20 stability 1. The kinase associates with centrosomes and spindle microtubules during mitosis, controlling essential processes including spindle assembly, centrosome duplication and separation, and chromosome 20 1. AURKA requires activation by regulatory proteins like TPX2, which forms a functionally important complex with AURKA that contributes to its localization, activation, and stabilization 1. Beyond its canonical mitotic functions, AURKA exhibits nuclear activity where it collaborates with transcription factors to promote oncogene expression 2. The kinase is frequently overexpressed in various cancers, including breast cancer (73% of patients), meningioma, and cholangiocarcinoma, where it contributes to tumorigenesis through multiple mechanisms 345. In cancer contexts, AURKA promotes malignant characteristics by suppressing ferroptosis through KEAP1 phosphorylation and NRF2 activation 4, and by stabilizing anti-apoptotic proteins 6. The frequent co-overexpression of AURKA with its regulator TPX2 in highly proliferative and aneuploid tumors underscores their importance as an oncogenic unit, making AURKA an attractive therapeutic target with multiple inhibitors under development 13.