BAG6 (BAG cochaperone 6) is a multifunctional protein that serves as a critical regulator of protein quality control and cellular stress responses. The protein functions as part of a ribosome-associated membrane protein triage complex that captures polypeptides with hydrophobic C-terminal tails, directing them for either proteasomal degradation or membrane targeting 1. BAG6 plays essential roles in protein quality control by promoting K48-linked ubiquitination and degradation of misfolded proteins, as demonstrated with influenza A virus PB2 protein 2 and C9orf72 protein stabilization 3. Beyond quality control, BAG6 exhibits tumor suppressor functions in pancreatic cancer by regulating extracellular vesicle biogenesis and preventing IL33-mediated mast cell activation 4. The protein also contributes to neuroprotection through synergistic interactions with MFN2, reducing reactive oxygen species levels and modulating autophagy during cerebral ischemia-reperfusion injury 5. BAG6 has been implicated in various disease contexts, including genetic susceptibility to irritable bowel syndrome 6 and sarcopenia through immune-related signaling pathways 7. Additionally, BAG6-containing exosomes facilitate muscle-bone communication during aging, highlighting its role in tissue crosstalk 8.