BLID (BH3-like motif containing, cell death inducer) is a proapoptotic tumor suppressor gene localized to chromosome 11.1 that functions through the caspase-dependent mitochondrial pathway 1. BLID contains a BH3-like motif characteristic of the Bcl-2 family and exerts its apoptotic function by directly interacting with the antiapoptotic protein Bcl-XL, leading to Bax activation and cytochrome c release 2. BLID expression is frequently downregulated across multiple cancer types, including breast cancer and non-small cell lung cancer, where reduced levels correlate with disease progression 13. In breast cancer specifically, BLID loss occurs in 32% of cases overall, but increases to 50% in early-onset patients (≤40 years), suggesting an age-dependent tumor suppressor role 4. Loss of BLID expression is independently associated with poor prognostic outcomes, including reduced disease-free and overall survival, and correlates with aggressive phenotypes such as triple-negative breast cancer and high tumor grade 2. MicroRNA-575 negatively regulates BLID expression in lung cancer, and BLID downregulation promotes cancer cell proliferation and invasion 5. These findings establish BLID as a critical apoptosis regulator with independent prognostic significance in cancer.