Based on limited published evidence, BOLA2B is a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins, functioning together with the monothiol glutaredoxin GLRX3 12. Beyond its canonical Fe-S cluster assembly role, BOLA2B expression is enriched in pathways associated with iron-sulfur cluster formation, mTOR-mediated autophagy, and cell cycle regulation 3. DNA methylation patterns near BOLA2B have been associated with maternal age effects on offspring epigenomes 4.