BRME1 (break repair meiotic recombinase recruitment factor 1) is a meiosis-specific protein essential for homologous recombination during germ cell development. Mechanistically, BRME1 functions as a stabilizer of the MEILB2 protein, preventing its self-association and enabling formation of the BRCA2-MEILB2-BRME1 ternary complex 1. This complex recruits and concentrates the recombinases RAD51 and DMC1 at meiotic double-strand break (DSB) sites 2. Structurally, BRME1 and MEILB2 form a V-shaped DNA clamp upon BRCA2 binding, with DNA-binding β-caps separated by 25 nm that bridge resected DNA ends to facilitate recombination 3. Additionally, BRME1 controls HSF2BP-BRCA2 oligomerization, ensuring timely assembly of recombination complexes 4. Loss of BRME1 destabilizes the BRCA2-MEILB2 complex, causing defective DSB repair, impaired homolog synapsis, and reduced crossover formation 1. Clinically, BRME1 mutations and reduced expression associate with primary ovarian insufficiency and male infertility 25. Beyond meiosis, somatic MEILB2-BRME1 expression in cancer cells impairs mitotic homologous recombination 1, and BRME1 expression correlates with cisplatin responsiveness in head and neck cancers 6.