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0 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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BUB1B-PAK6
BUB1B-PAK6 readthrough
Chromosome 15 · 15q15.1
NCBI Gene: 106821730Ensembl: ENSG00000137843.13HGNC: HGNC:16061UniProt: Q9NQU5
10PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLE
Kinase
DATA QUALITY
✓ Swiss-Prot Reviewed
mosaic variegated aneuploidy syndrome 1premature chromatid separation traitneuroinflammatory disordergenetic disorder
✦AI Summary

AI summary not yet available. Showing NCBI Gene summary.

BUB1B-PAK6 readthrough

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsⓘ20
mosaic variegated aneuploidy syndrome 1Open Targets
0.52Moderate
premature chromatid separation traitOpen Targets
0.27Weak
neuroinflammatory disorderOpen Targets
0.20Weak
genetic disorderOpen Targets
0.19Weak
colorectal cancerOpen Targets
0.18Weak
intestinal obstructionOpen Targets
0.12Weak
keratoconusOpen Targets
0.11Weak
microcephalyOpen Targets
0.11Weak
hypertrophic cardiomyopathyOpen Targets
0.11Weak
prostate cancerOpen Targets
0.10Suggestive
Parkinson diseaseOpen Targets
0.09Suggestive
hepatocellular carcinomaOpen Targets
0.08Suggestive
gastric cancerOpen Targets
0.08Suggestive
non-small cell lung carcinomaOpen Targets
0.08Suggestive
neoplasmOpen Targets
0.08Suggestive
colon carcinomaOpen Targets
0.07Suggestive
small cell lung carcinomaOpen Targets
0.07Suggestive
esophageal squamous cell carcinomaOpen Targets
0.06Suggestive
chronic myelogenous leukemiaOpen Targets
0.06Suggestive
cervical cancerOpen Targets
0.06Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
MAP2K1Protein interaction98%IQGAP1Protein interaction98%ARHGEF6Protein interaction97%LIMK2Protein interaction96%CDC42Protein interaction94%ROBO2Protein interaction93%
Tissue Expression6 tissues
Heart
100%
Bone Marrow
45%
Brain
10%
Lung
1%
Ovary
1%
Liver
0%
Gene Interaction Network
Click a node to explore
BUB1B-PAK6MAP2K1IQGAP1ARHGEF6LIMK2CDC42ROBO2
PROTEIN STRUCTURE
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PDB4KS7 · 1.40 Å · X-ray
View on RCSB ↗
RankingsWhere BUB1B-PAK6 stands among ~20K protein-coding genes
  • #17,000of 20,598
    Most Researched10
Genes detectedBUB1B-PAK6
Sources retrieved0 papers
Response time—