1 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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21PubMed Papers
12Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
protein bindingAlzheimer diseasetuberculosisacute myeloid leukemiahepatocellular carcinoma
Based on limited published evidence, C16orf87 (renamed MHAP1) is a protein containing intrinsically disordered regions that mediates protein-protein interactions. The protein binds to HDAC2 and MIER1, forming a stable chr16 remodeling complex 1. The C-terminal region of C16orf87 facilitates interactions with the ELM2 domain of MIER1 and the C-terminal domain of HDAC2, suggesting a role in chr16 regulation and transcriptional control through multi-protein complex assembly.
1
C16orf87 (MHAP1) forms a stable complex with HDAC2 and MIER1; contains intrinsically disordered regions that mediate protein-protein interactions in chromatin remodeling
PMID: 41928988⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.
Alzheimer diseaseOpen Targets
acute myeloid leukemiaOpen Targets
hepatocellular carcinomaOpen Targets
head and neck squamous cell carcinomaOpen Targets
metastatic melanomaOpen Targets
pancreatic adenocarcinomaOpen Targets
thyroid cancer, nonmedullary, 1Open Targets
No pathogenic variants reported on ClinVar for this gene.