C1QTNF6 (C1q and TNF related 6) is a member of the C1q/TNF-related protein (CTRP) family that functions as an oncogenic factor in multiple cancer types and plays roles in metabolic disorders. In cancer contexts, C1QTNF6 promotes tumor progression by enhancing cell proliferation, migration, and invasion while inhibiting apoptosis 123. The protein is overexpressed in various malignancies including non-small cell lung cancer, gastric carcinoma, and oral squamous cell carcinoma, where its knockdown results in cell cycle arrest at G2/M phase and increased apoptosis 123. C1QTNF6 is regulated by microRNAs including miR-184 and miR-29c-3p, which target and suppress its expression to inhibit cancer cell behaviors 45. Beyond oncology, C1QTNF6 has clinical relevance in metabolic diseases, with genetic polymorphisms in the gene associated with type 1 diabetes risk and beta-cell function in Chinese populations 6. The protein is also elevated in polycystic ovary syndrome as part of the inflammatory profile characteristic of this condition 7. These findings suggest C1QTNF6 serves as both a potential therapeutic target in cancer and a biomarker for metabolic dysfunction.