CAMLG (calcium modulating ligand) is a multifunctional protein with primary roles in protein trafficking and calcium signaling. Its canonical function involves tail-anchored (TA) protein insertion into the endoplasmic reticulum membrane, where it acts as a membrane receptor alongside GET1/WRB for the soluble chaperone GET3/TRC40 1. CAMLG is essential for GET1 stability and is required for survival of peripheral follicular B cells [UniProt annotations]. Beyond ER protein trafficking, CAMLG stimulates calcium signaling in T cells by regulating intracellular calcium elevation 2, and serves as a host target for pathogenic interactions, including with viral and bacterial proteins 34. Clinically, CAMLG is associated with multiple neurological and systemic disorders. Loss-of-function mutations cause CAMLG-CDG (congenital disorder of glycosylation), presenting with psychomotor disability, hypotonia, epilepsy, and combined glycosylation defects 1. CAMLG variants confer risk for Parkinson's disease through effects on lysosomal protein levels, with higher neuronal expression in Lewy body disease cases 5. Additionally, increased brain CAMLG protein abundance is causally associated with amyotrophic lateral sclerosis risk 6, while elevated CAMLG levels correlate with reduced insomnia risk 7. These findings suggest CAMLG dysfunction contributes to neurodegenerative disease pathogenesis through both membrane trafficking and cellular signaling mechanisms.