CAMTA1 (calmodulin binding transcription activator 1) is a transcriptional activator highly expressed in the brain that plays critical roles in cerebellar neuron development, cell cycle regulation, and memory formation 1. The protein functions as a tumor suppressor in gliomas by inhibiting AKT phosphorylation and regulating cell proliferation and cell cycle progression 2. CAMTA1 is involved in the calcineurin-NFAT signaling cascade and binds double-stranded DNA to regulate transcription by RNA polymerase II. Pathogenic variants in CAMTA1 cause cerebellar dysfunction with variable cognitive and behavioral abnormalities (CECBA), characterized by developmental delay, intellectual disability, unsteady gait, hypotonia, and behavioral problems 1. The disorder shows incomplete penetrance and variable expressivity, with over one-third of variants inherited from asymptomatic or mildly affected parents 13. Additionally, CAMTA1 is involved in oncogenic gene fusions, particularly the WWTR1-CAMTA1 fusion found in >90% of epithelioid hemangioendotheliomas, where it drives tumor formation through TAZ dysregulation 45. CAMTA1 variants have also been associated with increased periodontal disease susceptibility and shared inflammatory pathways with cardiovascular diseases 6.