CAMTA2 (calmodulin-binding transcription activator 2) is a transcription coactivator that regulates gene expression through interaction with transcription factors and chr17-modifying complexes. As a calmodulin-binding protein, CAMTA2 functions downstream of calcium signaling to modulate transcription of target genes 1. In cardiac tissue, CAMTA2 serves as an indispensable transcription coactivator for cardiac hypertrophy, working through interaction with the transcription factor Nkx2-5 to promote expression of hypertrophy-associated genes 12. A functional variant (rs238234) in CAMTA2's coding region increases left ventricular hypertrophy susceptibility in hypertensive patients by enhancing Nkx2.5-dependent transcription 2. In colon cancer, CAMTA2 expression is elevated and correlates with poor prognosis; knockdown of CAMTA2 suppresses cancer cell proliferation and migration via inhibition of Wnt/β-catenin signaling 3. CAMTA2 is regulated post-transcriptionally by miR-28-5p, and this regulatory axis represents a potential therapeutic target 3. Conversely, mutations causing reduced CAMTA2 expression cause syndromic neurological disease with tremor, dystonia, and spasticity 4. Additionally, CAMTA2 participates in stress-responsive pathways, including aluminum-induced malate secretion in plants and environmental signal integration in light-temperature sensing 56.