CCDC136 is a testis-specific gene essential for male reproduction, primarily functioning in acrosome formation during spermatogenesis 1. The protein localizes abundantly to the acrosome of round and elongating spermatids 1. CCDC136 knockout mice are infertile due to severe acrosome formation defects, with significantly downregulated expression of acrosome-related proteins SPACA1 and PICK1 1. Additionally, anti-CCDC136 antibodies inhibit fertilization in vitro, indicating the protein's critical role in sperm-egg interaction 1. Beyond reproduction, CCDC136 has been associated with reading and language abilities. Genome-wide association studies identified the CCDC136/FLNC locus as significantly associated with reading and language phenotypes 2. Rare damaging variants in CCDC136 were enriched in individuals with reading disability 3, and neuroimaging analyses found associations between CCDC136/FLNC variants and altered cortical thickness in language-related brain regions 4. CCDC136 expression has also been linked to cancer prognosis. In colon cancer, CCDC136 expression correlated with patient survival outcomes 5, and in multiple myeloma, CCDC136 was identified as a PRC2 target gene involved in tumor suppressor pathways 6.