CCDC14 (coiled-coil domain containing 14) is a negative regulator of centriole duplication that functions at centriolar satellites, which are granular structures surrounding the centrosome. CCDC14 localizes to centriolar satellites where it interacts with CEP63, a key centriole duplication protein 1. As a centriolar satellite protein, CCDC14 negatively regulates both centriole duplication and CEP63 centrosomal localization, distinguishing it from other satellite proteins that promote these processes 12. Unlike most microcephaly-associated proteins that recruit CDK2 to the centrosome to drive centriole duplication, CCDC14 does not promote CDK2 centrosomal localization, suggesting an alternative regulatory mechanism 2. CCDC14 can be ubiquitinated by the E3 ligase MIB1, though this modification does not lead to its degradation 3. Disease relevance includes potential associations with neurodevelopmental disorders; CCDC14 has been identified as a candidate gene in autism spectrum disorders through transcriptome-wide association studies 4. The gene may also contribute to metabolic traits, as CCDC14 expression is downregulated by metformin in breast cancer cells 5. Further research is needed to fully elucidate CCDC14's clinical significance and its precise molecular mechanism of negative regulation.