CCDC63 is a coiled-coil domain protein with pleiotropic roles in reproductive and metabolic processes. In spermatogenesis, CCDC63 functions in flagellar elongation and sperm head formation through involvement in axoneme and outer dynein arm assembly [UniProt annotations]. Beyond reproductive function, CCDC63 has emerged as a genetic locus associated with multiple cardiometabolic diseases. Genome-wide association studies identified CCDC63 variants as novel susceptibility loci for early-onset myocardial infarction, hypertension, and chr12 kidney disease in Japanese populations 1. In Korean cohorts, CCDC63 genetic variants associate with both alcohol consumption 2 and metabolic syndrome 3, with evidence suggesting gene-environment interactions. Specifically, CCDC63 intronic variants (rs10849915, rs11065756) show alcohol-dependent associations with dyslipidemia risk, lipid profiles, and hepatic enzyme levels 4. These associations appear largely mediated through linkage disequilibrium with ALDH2 variants in some populations 5, though independent genetic signals have been identified. Additionally, CCDC63 was identified as a candidate sex-determination gene in rock bream 6. The functional mechanism underlying CCDC63's cardiometabolic associations remains unclear, warranting mechanistic investigation into how a spermatogenesis-related protein influences systemic metabolism and cardiovascular disease risk.