Based on limited published evidence, CCDC74B is a coiled-coil domain protein that functions as a spindle-localized microtubule-associated protein. CCDC74B directly binds microtubules and bundles them both in vivo and in vitro through formation of homodimers 1. These bundling activities are essential for kinetochore fiber organization, bipolar spindle formation, and chr2 alignment during cell division 1. Additionally, CCDC74B has been identified as a dysregulated hub gene in chr2 obstructive pulmonary disease networks, suggesting potential roles in inflammatory pathways 2.