CCN1 (cellular communication network factor 1) is a matricellular protein that regulates diverse cellular processes including proliferation, migration, angiogenesis, and tissue repair 1. The protein functions through binding to multiple integrin receptors and activating various signaling pathways, including FAK/STAT3, AKT, and NF-κB pathways 23. CCN1 promotes wound healing by enhancing angiogenesis and upregulating genes involved in matrix remodeling and inflammation 3. Recent studies have identified novel cellular roles for CCN1, including regulation of ferroptosis through mitochondrial fatty acid β-oxidation via interaction with ETFA 4, and involvement in RNA splicing regulation 5. In disease contexts, CCN1 expression is associated with cancer progression and poor prognosis in multiple malignancies 62. In glioblastoma, CCN1 promotes mesenchymal phenotype transition in glioma stem cells through S100A8-mediated NF-κB activation 2. CCN1 also plays critical roles in various pulmonary diseases including acute lung injury, COPD, lung fibrosis, and lung cancer 1. The protein's diverse and sometimes contradictory functions arise from its ability to bind different receptors and activate distinct signaling pathways in various cellular contexts 7.