HomeAboutRankingsData Sources
© 2026 GeneE
🧬
GeneE
10 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
ⓘGeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
CCNJ
cyclin J
Chromosome 10 · 10q24.1
NCBI Gene: 54619Ensembl: ENSG00000107443.17HGNC: HGNC:23434UniProt: Q5T5M9
15PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
cyclin-dependent protein serine/threonine kinase regulator activityG1/S transition of mitotic cell cyclenucleuscytoplasmAbnormality of the skeletal systemneurodegenerative diseasealcohol drinkingstroke
✦AI Summary

CCNJ (cyclin J) is a cell cycle regulatory protein functioning as a cyclin-dependent protein kinase regulator involved in G1/S transition and mitotic cell cycle progression 1. CCNJ localizes to the cytoplasm, nucleus, and microtubule organizing centers, where it regulates cyclin-dependent serine/threonine kinase activity. The protein controls cell mitosis and proliferation through its role in cell cycle checkpoint regulation 2. CCNJ is dysregulated across multiple human malignancies through distinct mechanisms. In hepatocellular carcinoma (HCC), CCNJ promoter hypermethylation (78.8% of tumors) leads to decreased expression and correlates with worse overall survival 1. In breast cancer, CCNJ is overexpressed in ~20% of tumors and serves as a direct target of the tumor suppressor miR-125b 3. Similarly, CCNJ is targeted by miR-125a in HCC cells 4, miR-16 in ErbB-2-positive breast and gastric cancer 5, miR-146a in cisplatin-resistant lung cancer 6, and miR-98 in prostate cancer 2. Upregulation of these regulatory miRNAs suppresses CCNJ expression, inhibiting cell proliferation and enhancing drug sensitivity. Clinically, CCNJ represents a promising prognostic marker and therapeutic target in HCC and other cancers, with potential utility in predicting chemotherapy response and identifying candidates for miRNA-based therapeutics.

Sources cited
1
CCNJ promoter hypermethylation in 78.8% of HCC tumors correlates with decreased expression and worse overall survival
PMID: 25672416
2
miR-146a downregulates CCNJ to increase cisplatin sensitivity in non-small cell lung cancer cells
PMID: 28202053
3
miR-125b targets CCNJ to suppress breast cancer cell proliferation and G2/M cell cycle arrest
PMID: 24098452
4
miR-16 targets CCNJ to mediate trastuzumab and lapatinib response in ErbB-2-positive breast and gastric cancer
PMID: 27157613
5
miR-183/96/182 cluster downregulates CCNJ as part of retinal cell differentiation pathways
PMID: 37119770
6
miR-125a-5p targets CCNJ as a novel oncogene in hepatocellular carcinoma
PMID: 39858538
7
CCNJ protein controls cell mitosis and is downregulated by miR-98 to induce G2/M arrest in prostate cancer
PMID: 23188821
Disease Associationsⓘ20
Abnormality of the skeletal systemOpen Targets
0.47Moderate
neurodegenerative diseaseOpen Targets
0.36Weak
alcohol drinkingOpen Targets
0.09Suggestive
strokeOpen Targets
0.04Suggestive
attention deficit hyperactivity disorderOpen Targets
0.03Suggestive
substance abuseOpen Targets
0.03Suggestive
non-small cell lung carcinomaOpen Targets
0.03Suggestive
hepatocellular carcinomaOpen Targets
0.02Suggestive
breast cancerOpen Targets
0.02Suggestive
urinary bladder carcinomaOpen Targets
0.02Suggestive
neoplasmOpen Targets
0.02Suggestive
medulloblastomaOpen Targets
0.01Suggestive
osteosarcomaOpen Targets
0.01Suggestive
cancerOpen Targets
0.01Suggestive
breast neoplasmOpen Targets
0.01Suggestive
primitive neuroectodermal tumorOpen Targets
0.01Suggestive
prostate cancerOpen Targets
0.01Suggestive
acute lymphoblastic leukemiaOpen Targets
0.00Suggestive
Bloom syndromeOpen Targets
0.00Suggestive
gastric cancerOpen Targets
0.00Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
CCNG2Shared pathway100%CCNI2Shared pathway100%CCNB3Shared pathway100%CCNPShared pathway100%CCNJLShared pathway100%CCNG1Shared pathway50%
Tissue Expression6 tissues
Bone Marrow
100%
Lung
23%
Heart
21%
Ovary
20%
Brain
19%
Liver
12%
Gene Interaction Network
Click a node to explore
CCNJCCNG2CCNI2CCNB3CCNPCCNJLCCNG1
PROTEIN STRUCTURE
Preparing viewer…
AlphaFoldAI-predicted · UniProt Q5T5M9
View on AlphaFold ↗
Constraintⓘ
LOEUFⓘ
0.50Moderately Constrained
pLIⓘ
0.98Intolerant
Observed/Expected LoF0.31 [0.20–0.50]
RankingsWhere CCNJ stands among ~20K protein-coding genes
  • #15,511of 20,598
    Most Researched15
  • #2,968of 17,882
    Most Constrained (LOEUF)0.50 · top quartile
Genes detectedCCNJ
Sources retrieved10 papers
Response time—
📄 Sources
10▼
1
CCNJ detected by triple combination array analysis as a tumor-related gene of hepatocellular carcinoma.
PMID: 25672416
Int J Oncol · 2015
1.00
2
Up-regulation of miR-146a increases the sensitivity of non-small cell lung cancer to DDP by downregulating cyclin J.
PMID: 28202053
BMC Cancer · 2017
0.90
3
miR-125b acts as a tumor suppressor in breast tumorigenesis via its novel direct targets ENPEP, CK2-α, CCNJ, and MEGF9.
PMID: 24098452
PLoS One · 2013
0.80
4
The CC2D2B is a novel genetic modifier of the clinical phenotype in patients with hereditary angioedema due to C1 inhibitor deficiency.
PMID: 38679185
Gene · 2024
0.70
5
MiR-16 mediates trastuzumab and lapatinib response in ErbB-2-positive breast and gastric cancer via its novel targets CCNJ and FUBP1.
PMID: 27157613
Oncogene · 2016
0.60