CDON (cell adhesion associated, oncogene regulated) is a transmembrane glycoprotein and immunoglobulin superfamily member functioning as a cell-surface receptor in cell-cell communication and developmental signaling 1. As a component of the Hedgehog signaling receptor complex, CDON associates with ligand and other Hh receptor components including Ptch and Gas1 1. Beyond Hedgehog signaling, CDON suppresses canonical Wnt/β-catenin signaling through its immunoglobulin domain 2, thereby regulating multiple physiological processes 23. In myogenic cells, CDON promotes satellite cell proliferation and muscle regeneration by regulating integrin β1 activation and FGF receptor signaling 4. CDON deficiency impairs these processes, leading to cardiac fibrosis and remodeling 3, impaired vascular smooth muscle cell calcification control 2, and defective muscle regeneration with senescence 4. Clinically, CDON mutations cause holoprosencephaly, a congenital forebrain midline defect associated with diminished Hedgehog pathway activity 1, and have been identified in pituitary stalk interruption syndrome with cranial nerve involvement 5 and isolated ocular coloboma 6. NFIB transcription factor represses CDON expression in neuroblastoma cells, where CDON acts as a tumor suppressor 7.